Research Opportunities

GC Image, LLC - Bionformatics for Metabolomic Analyses

SBIR Award Title

SBIR Phase II: Sample Classification and Biomarker Discovery by Comprehensive Metabolomic Analysis

SBIR Award Abstract

This Small Business Innovation Research Phase II project proposes to develop a system for automated classification of biological samples and discovery of biomarkers. The system will be designed to perform comprehensive pattern analysis of state-of-the-art biochemical separations generated by comprehensive two-dimensional chromatography (GCxGC) with high-resolution mass spectrometry (HRMS). The pairing of GCxGC and HRMS combines highly effective molecular separations with precise elemental analysis. A critical challenge... more

Research Opportunity

Bionformatics for Metabolomic Analyses
1
Yes

Address

201 N 8 ST, Suite 420
Lincoln
NE
68508

Officer

Stephen Reichenbach
reich@gcimage.com
4023104503

Principal Investigator

Stephen Reichenbach
reich@gcimage.com
4023104503

Description

GC Image, LLC, is developing informatics for automated classification of biological samples and discovery of biomarkers. The system performs comprehensive pattern analysis of state-of-the-art biochemical separations generated by comprehensive two-dimensional gas chromatography (GCxGC) and comprehensive two-dimensional liquid chromatography (LCxLC) with high-resolution mass spectrometry (HRMS). The pairing of GCxGC or LCxLC with HRMS combines highly effective molecular separations with precise elemental analysis. By developing and disseminating improved informatics for biological classification and biomarker discovery, this project will enable applications researchers to better understand biochemical processes and to discover metabolomic biomarkers for improved methods for disease diagnoses and treatments.

The post-doctoral researcher will work with the R&D team at GC Image, LLC, to develop and demonstrate innovative methods and tools for bioinformatics data processing, visualization, and analysis. This work is conducted in collaboration with advanced research laboratories in prominent universities and leading companies world-wide and the results of the research are presented at premier conferences and published in top journals. Some time will be allowed for independent research and GC Image, LLC, will support application for adjunct faculty status at the University of Nebraska - Lincoln during the award.

Desired Knowledge

The successful candidate should fit one of two profiles:

* Education and background in computer science, software engineering, or related disciplines.

* Education and background in analytical chemistry, biochemistry, biosciences (esp. metabolomics), or related disciplines.

For candidates with primarily a computing background, prior work in data science, pattern recognition, machine learning, or related areas is desired, but not required.

For candidates with primarily a biochemical science background, prior work in chromatography, mass spectrometry, metabolomics, or related areas is desired, but not required.

For all candidates, prior work in bioinformatics, cheminformatics, and chemometrics is desired, but not required.

For all candidates, the ability to program in a high-level language, preferably Java and/or R, is required.

Apply to this research opportunity